Diaphoresis is a therapy by sweating and ventilating the lung to dispel exogenous evils，removing the six exogenous pathogenic factors with sweat. Since ancient times, diaphoresis was used for treating exterior syndrome and incomplete appearance of rashes with aversion to cold, fever, headache and pruritus. After many years of clinical experience, master of Traditional Chinese Medicine Li Shimao puts forward the innovative personal concepts on the diaphoretic therapy. Under the guidance of the normal pulse differentiation，he applies diaphoresis to treat interior syndrome, deficiency-excess mixing syndrome, Yang deficiency and coagulated cold syndrome. This therapeutic principle does not limit itself in treating exterior syndrome, thus enriches theoretical research of diaphoresis, expands the scope of application of diaphoresis, and obtains satisfactory curative effect in clinical practice.