Peng Wannian is professor and PhD supervisor at the First Affiliated Hospital of Guangzhou University of Chinese Medicine, who is engaged in Chinese medicine clinical practice, teaching and scientific research for more than 30 years. He devotes to studying Qihuang’s medical skill, exploring ascending and descending Qi activity theory, following Zhang Zhongjing’s clinical experience with exclusive dialectical precision to obtain good effect. Combining with his clinical experience, the author gained a lot because of his understandings. For promoting the application of the method of Ascending and Descending Qi activity theory, the author tried to share his experience with others. Through the analysis of three cases of treating intractable disease, the author could help the clinical doctors to treat the disease.