“Earth stagnation, wood depression” is one of the pathological relationships of the liver and the spleen, and is related to the occurrence and development of many diseases. Usually, this mechanism occurs in some liver diseases: the spleen and the stomach are attacked first, and then the liver is involved. The pathogenesis of “earth stagnation, wood depression” exists in the occurrence and development of many liver diseases, such as viral hepatitis B, alcoholic liver disease, fatty liver, etc. Through the discussion of “earth stagnation, wood depression” pathogenesis and its application in clinical liver diseases, the clinical significance of this mechanism can be proved. Increasing the understanding of this pathogenesis guides clinical diagnosis and treatment, and improves the curative effect.