| 引用本文:李立华1，刘晓燕2，郭霞珍2，杨云霜3.气候突变对脑卒中大鼠发病的影响[J].世界中医药,2015,10(03):. |
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| 气候突变对脑卒中大鼠发病的影响 |
| Effect of Abrupt Climate Change on the Incidence of Cerebral Stroke in Rats |
| 投稿时间：2014-03-10 |
| DOI：10.3969/j.issn.1673-7202.2015.03.027 |
| 中文关键词: 气候突变 脑卒中 易卒中型肾性高血压大鼠 |
| English Keywords:Abrupt climate change Cerebral stroke RHRSP |
| 基金项目:北京市自然科学基金项目（编号：7072038） |
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| 中文摘要: |
| 目的：改进易卒中型肾性高血压大鼠的造模方法，并在此研究上气候突变对脑卒中大鼠发病的影响。方法：不完全暴露肾脏，以体表定位的方法寻找双肾动脉，复制易卒中型肾性高血压大鼠模型（RHRSP），待大鼠血压升高到一定程度把它们放置于人工模拟气候箱中，给予气温骤然升降的刺激，观察脑卒中大鼠发病情况。结果：改进后的造模方法使大鼠术后死亡率低，血压升高快，卒中率高。气温骤升组的模型组大鼠血压值在造模45 d左右稳定在220～230 mmHg之间，气温骤降组的模型组大鼠血压值稳定在205～220 mmHg之间；模型组与生理组，假手术组的血压值有统计学意义（P<0.05）。气温骤然升降的变化影响RHRSP脑梗死及脑出血发生的几率。结论：采用体表定位的方法，可以减少大鼠的并发症及死亡率并且提高大鼠的脑卒中发生率。血压升高、气候突变的刺激是脑血管疾病发病的一个重要诱因；气温骤然升降可导致两种不同的结局：气温骤升导致RHRSP发生脑梗死的几率稍高，而气温骤降导致该模型大鼠脑出血发病率稍高。 |
| English Summary: |
| To explore how to improve the model of RHRSP, and the effect of abrupt climate change on the incidence of cerebral stroke in rats. Methods: Body surface location method was used to locate the double renal arteries without exposing the kidney. “RHRSP” rat model was made and then put into an artificial climate simulation box, the incidence of the stroke was observed when the temperature was increased or decreased abruptly. Results: The improved model making method caused low death rate, quick blood pressure rise and high stroke rate. The blood pressure was stabilized to between 220 and 230mmHg after the model was made for around 45d in the sharp temperature rise group, and 205-220mmHg in the sharp temperature drop group; the blood pressure values were statistically significant(P<0.05) in the model group, physiology group and sham-operation group. Sudden temperature change affected the incident rate of cerebral infarction and cerebral hemorrhage in RHRSP. Conclusion: Body surface location method can decrease complication in rats and death rate as well as increasing the incidence rate of cerebral stroke in rats. Blood pressure elevation and abrupt climate change are important inducements to cause cerebrovascular disease; sudden temperature change can cause two different Results: there is high incidence of cerebral infarction in RHRSP when the temperature rises sharply and high incidence of intracerebral hemorrhage when the temperature drops suddenly. |
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