Abstract:To explore how to improve the model of RHRSP, and the effect of abrupt climate change on the incidence of cerebral stroke in rats. Methods: Body surface location method was used to locate the double renal arteries without exposing the kidney. “RHRSP” rat model was made and then put into an artificial climate simulation box, the incidence of the stroke was observed when the temperature was increased or decreased abruptly. Results: The improved model making method caused low death rate, quick blood pressure rise and high stroke rate. The blood pressure was stabilized to between 220 and 230mmHg after the model was made for around 45d in the sharp temperature rise group, and 205-220mmHg in the sharp temperature drop group; the blood pressure values were statistically significant(P<0.05) in the model group, physiology group and sham-operation group. Sudden temperature change affected the incident rate of cerebral infarction and cerebral hemorrhage in RHRSP. Conclusion: Body surface location method can decrease complication in rats and death rate as well as increasing the incidence rate of cerebral stroke in rats. Blood pressure elevation and abrupt climate change are important inducements to cause cerebrovascular disease; sudden temperature change can cause two different Results: there is high incidence of cerebral infarction in RHRSP when the temperature rises sharply and high incidence of intracerebral hemorrhage when the temperature drops suddenly.