To establish the quality standards for Xiao’er Ganmao Granules. Methods: Pogostemonis herba, chrysanthemi flos, and forsythiae fructus were identified with TLC. Phillyrin was meatured by HPLC. DiamonsilTM C18 (5 μm，4.6 mm×250 mm) column was used. The column temperature was at 30 ℃. Acetonitrile-water (24∶76) was used as a mobile phase. The detection wavelength was at 202 nm. The flow rate was 1.0 mL/min. Results: Patchouli alcohol, chrysanthemi flos, and forsythiae could be detected by TLC, with the feature spot obvious, negative interference-free. Phillyrin showed a good linear relationship at the range of 0.02362～0.5905μg，r=0.99999 (n=6)，The average recovery rate was 99.06％ and RSD was 1.5％. Conclusion: TLC method proves to be simple, accurate and with good reproducibility, thus can be used for quality control of Xiao，er Ganmao Granule.