| 引用本文:史梅莹1，赵燕1，王天芳1，李昕2，吴昊1，任红1.基于复杂网络分析现代文献报道的中医周期疗法治疗多囊卵巢综合征的用药规律[J].世界中医药,2015,10(03):. |
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| 基于复杂网络分析现代文献报道的中医周期疗法治疗多囊卵巢综合征的用药规律 |
| Modern Literature Research on the Rule of Prescription for Polycystic Ovary Syndrome Treated with TCM Periodic Therapy |
| 投稿时间：2014-10-26 |
| DOI：10.3969/j.issn.1673-7202.2015.03.036 |
| 中文关键词: 多囊卵巢综合征 复杂网络 中医周期疗法 用药规律 |
| English Keywords:PCOS Complex network TCM periodic therapy Literature research |
| 基金项目:北京中医药大学自主课题（编号：53210100604233）；北京中医药大学科研创新团队项目（编号：2011CXTD08） |
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| 中文摘要: |
| 目的:通过现代文献研究,分析中医周期疗法治疗多囊卵巢综合征(PCOS)的用药特点,为提高PCOS的临床疗效提供依据。方法:对2000—2014年的相关临床研究文献进行检索,应用Excel软件,对周期治疗PCOS中所用中医复方及其药物建立数据库,运用SPSS对数据进行处理,使用复杂网络挖掘中医周期疗法中治疗PCOS的核心药物,分析其用药特点。结果:1)符合纳入标准的文献有51篇,其中41篇分4期治疗,10篇分3期治疗,共涉及药物151味,出现频率≥2%有当归、菟丝子、熟地黄、山药、香附、淫羊藿、川芎、山茱萸、丹参、枸杞子、茯苓和苍术。2)分期治疗常用配伍组合的药物(关联频度≥20%)依次为:经后期:当归、菟丝子、熟地黄、山药、淫羊藿、女贞子、枸杞子、山茱萸、香附、何首乌;经间期:当归、菟丝子、熟地黄、丹参、红花、山药、山茱萸、桃仁、川芎、赤芍、白芍、茯苓、香附、皂角刺、淫羊藿;经前期:当归、菟丝子、熟地黄、山药、淫羊藿、枸杞子、肉苁蓉、山茱萸、川断、何首乌、杜仲、香附;行经期:当归、赤芍、益母草、泽兰、香附、丹参、川芎、红花、桃仁、熟地黄。结论:通过复杂网络分析所获得的临床报道所用中医周期治疗PCOS的用药规律,体现了该病病理因素主要是(阳)虚、血瘀和痰湿;病位主要肾、肝、脾。分期治疗治法分别为:经后期以补肝肾,滋阴养血,理气健脾为主;经间期以补肝肾,理气活血为主;经前期以补肾升阳、健脾理气为主;行经期活血滋阴为主,可为进一步指导临床用药提供一定的指导。 |
| English Summary: |
| To analysis the rule of prescription for PCOS treated by TCM periodic therapy, and to provide the basis for the improvement of clinical curative effect by analyzing clinical literature. Methods: The authors searched the clinical literature of PCOS, built up a literature data-base by Excel software, processed by SPSS and ana1yzed by Pajek. Results: (1) 51 articles met the inclusion criteria, among which 41 were divided treatment into 4 periods, and another 10 articles divided treatment into 3 periods. The articles all-together included to 151 Traditional Chinese Medicine herbs, among which Chinese angelica, dodder, prepared rehmannia root, Chinese yam, Rhizoma Cyperi, epimedium, chuanxiong rhizome, dogwood, Salvia miltiorrhiza, wolfberry fruit, Poria and Rhizoma Atractylodis appeared with a greater percentage than or equal to 2%. (2) The following were the combination of herbs that were commonly used for the treatment of PCOS (their association frequency were greater than or equal to 20%). The follicular phase: dodder, prepared rehmannia root, Chinese angelica, Chinese yam, epimedium, glossy privet fruit, wolfberry fruit, dogwood, rhizoma cyperi, radix polygoni multiflori; Ovulation: dodder, prepared rehmannia root, angelica, safflower, danshen, Chinese yam, cornus, peach seed, chuanxiong, radix paeoniae rubra, radix paeoniae alba, poria, rhizoma cyperi, spina gleditsiae, epimedium; Luteal phase: dodder, prepared rehmannia root, Chinese angelica, Chinese yam, wolfberry fruit, epimedium, cistanche, dogwood, himalayan teasel root, eucommia, rhizoma cyperi, radix polygoni multiflori; Menstrual period: angelica, radix paeoniae rubra, radix salviae miltiorrhizae, rhizoma cyperi, motherwort herb, herba lycopi, chuanxiong, safflower, peach seed, radix rehmanniae preparata. Conclusion: Analyzing the prescription rules for PCOS treatment with TCM periodic therapy showed that the pathological factors were (Yang) deficiency, blood stasis and phlegme; the location of disease were kidney, liver, spleen; the main rules of treatment in follicular phase period were reinforcing liver and kidney, nourishing yin and blood, and regulating qi-flowing for strengthening spleen; the mainly rules of treatment in ovulation were reinforcing liver and kidney, nourishing qi and activating blood ; the mainly rules of premenstrual phase were rising the kidney yang, and regulating qi-flowing for strengthening spleen; In menstrual period the rules were mainly activating blood and nourishing Yin. The results can provide some guidance for clinical practice. |
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