Effective wound healing has been a lasting and challenging topic in health care. Various strategies have been used to accelerate and perfect the healing process. One such strategy has involved the application of an exogenous electrical stimulus to chronic wounds with the aim of stimulating healing responses. The biology of electric stimulation to instigate healing, however, is very poorly understood. This study provides theoretical support to the treatment of diabetic skin lesions, senile and refractory ulcer with electric stimulation.