To analyze acupoints selection and rules of acupuncture treatment for Perimenopausal Syndrome (PMS) in ancient Chinese history.Methods:We identified data source, established data collection criteria, standardized verbatim of diseases names, symptoms names and acupoints names, retrieved acupuncture treatment of PMS from ancient literatures. By using “Acupuncture Evidence-based Clinical Decision Making Support Platform” we performed extensive data minging.Results:There had been a preliminary understanding of PMS since Tang dynasties. Acupoints selection in Ming and Qing were similar to those of modern times. All fourteen meridians were selected, and ren meridian ranked first. Specific acupoints accounted for 90.65% of all acupoints treatment (737/813), most frequently used were intersection points followed by five shu points. Most frequently treated acupoinst include Sanyinjiao(SP6), Qihai(RN6), Zhongji(RN3), Baihui(DU20) and Guan yuan(RN4).Conclusion:The ancient acupuncture treatment of PMS showed following features:ren meridian is the mainly treated meridians, kidney meridian, spleen meridian, bladder meridian, Du meridian can be added if needed. Jin and Ming focused more on enhance stomach qi; Tang, Song and Qing on kidney nurturing. In most cases specific acupoints were treated in combination with near or farther acupoints of syndrome differentiation.