| 引用本文:樊海龙，赵凌，任玉兰，梁繁荣.针灸防治心肌缺血再灌注损伤的线粒体通路研究进展[J].世界中医药,2015,10(04):. |
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| 针灸防治心肌缺血再灌注损伤的线粒体通路研究进展 |
| Acu-moxibustion Prevention and Control of Injured Mitochondrial Pathway due to Myocardial Ischemia-Reperfusion |
| 投稿时间：2015-03-02 |
| DOI：10.3969/j.issn.1673-7202.2015.04.006 |
| 中文关键词: 针灸 心肌缺血再灌注损伤 线粒体功能障碍 线粒体通路 细胞信号转导 |
| English Keywords:Acu-moxibustion Myocardial ischemia-reperfusion injury Mitochondrial dysfunction Mitochondrial Pathway Cellular signal transduction |
| 基金项目:国家重点基础研究发展计划（973计划）项目（编号：2012CB518501）；国家自然基金面上项目（编号：81373561）；四川省科技厅项目（编号：2011SZ0302）；成都市科技计划项目（编号：12DXYB215JH-002） |
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| 中文摘要: |
| 目的：探讨针灸防治心肌缺血再灌注损伤的线粒体细胞信号转导机制，为后续研究提供思路。方法:通过对近年来国内外有关线粒体心脏损伤的研究入手，分析针灸防治心肌缺血再灌注损伤的线粒体通路的研究进展。结果：研究多以大鼠为观察对象，主要从针刺改善线粒体功能，减少线粒体活性氧类（ROS）产生过量引起氧化应激，防止细胞内Ca2+超载和阻止线粒体通透性转换孔（mPTP）的开放等角度切入研究。结论：微小RNA(microRNA，miRNA)是基因网络、蛋白网络、代谢网络等的上游网络的调控环节。鉴于针灸作用的整体性特点，将miRNA引入针灸作用机制研究领域，可在基因或其他水平层面更好地揭示针灸作用机制。 |
| English Summary: |
| To investigate acu-moxibustion protection of mitochondrial cellular signal transduction dysfunction due to myocardial ischemia-reperfusion injury.Methods:The research was made by studying research results published in recent years.Results:Most research used rats as study subjects and found acupuncture can improve mitochondria function, reduce mitochondrial reactive oxygen species (ROS) which caused excessive oxidative stress, prevent the intracellular Ca2+ overload and the mitochondrial permeability transition pore (mPTP) open.Conclusion:MicroRNA (miRNA) is the control factor of such upstream networks as genetic networks, protein networks, and metabolic networks. Given the overall characteristics of acupuncture effect, introducing the miRNA into the acupuncture mechanism research can better reveal acupuncture mechanism. |
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