This paper analyzed application of data mining in research of acupuncture and moxibustion by searching related literature since 2006. The results showed that data mining technology has obvious advantages in processing massive and nonliner data and renew traditional Chinese medicine knowledge. The shortcomings of acupuncture data mining include lack of multiple mining methods, massive data and uneven data quality. Using Complex network to discover acupoints combination rules and expand data mining research scope from multidisciplinary perspectives to reveal the mechanism of acupuncture and moxibustion can be future development directions