To observe the clinical curative effect of the compound salvia miltiorrhiza injection in adjuvant therapy of severe acute pancreatitis (SAP).Methods: Fifty patients with SAP were received and treated in our hospital.They were randomly divided into the control group and the treatment group.Both groups received conventional treatment,i.e.fasting,gastrointestinal decompression,expansion of blood volume,correction of electrolyte disturbances,anti-infection therapy,inhibition of pancreatic secretion,nutritional support,etc.On top of conventional treatment,the treatment group received intravenous drip of 20 ml compound salvia miltiorrhiza injection combined with 250ml 0.9% NaCl solution,once per day.Both groups received 10 days of treatment,and were observed of the changes in symptoms,signs and laboratory indexes before and after treatment.Results: 1) First defecation time,bowel sound recovery time,and abdominal tenderness disappear time of the treatment group were shorter than that of the control group,and the differences were statistically significant (P<0.05); 2) Complications rate,surgical operation rate and case fatality rate of the two groups were with statistical differences (P<0.05); 3) In the treatment group,the time of plasma endotoxin,serum amylase,the leukocyte count all returned to normal,which were better than that of the control group (P<0.05).After treatment,serum Tumor Necrosis Factor alpha (TNF alpha),interleukin-8 (IL-8) and interleukin-6 (IL-6) level of the treatment group were significantly lower than that of the control group (P<0.05).Conclusion: The application of compound salvia miltiorrhiza injection in the adjuvant therapy of SAP can promote the recovery of gastrointestinal function and reduce the incidence of complications and case fatality,thus is suggested to be further promoted in clinical practice.