世界中医药

目的：观察复方丹参注射液辅助治疗重症急性胰腺炎（Severe Acute Pancreatitis，SAP）的临床疗效。方法：将本院收治的50例SAP住院患者为研究对象，并根据入院先后顺序随机分为对照组和治疗组，2组患者均接受内科常规治疗，如禁食、胃肠减压、扩容、纠正电解质紊乱、抗感染、抑制胰腺分泌、营养支持等，治疗组在上述常规治疗基础上加用复方丹参注射液20 mL联合0.9%Nacl溶液250 mL静脉滴注，每日1次。2组均以10 d为1个疗程，1个疗程结束后观察2组患者治疗前后症状、体征以及实验室指标的变化。结果：1）治疗组首次排便的时间、肠鸣音恢复时间、腹部压痛消失时间均短于对照组，且差异有统计学意义（P<0.05）；2）2组并发症发生率、外科手术中转率及病死率比较均具统计学意义（P<0.05）；3）治疗组治疗组血浆内毒素、血清淀粉酶、白细胞计数恢复正常的时间均短于对照组（P<0.05），经过治疗后治疗组血清肿瘤坏死因子-α(Tumor Necrosis Factor alpha，TNF-α)、白细胞介素-8(Interleukin-8,IL-8)、白细胞介素-6(Interleukin-6，IL-6)水平明显低于对照组（P<0.05）。结论：复方丹参注射液辅助治疗SAP可促进胃肠功能恢复，降低并发症发生率及病死率，临床可进一步推广。

English Summary:

To observe the clinical curative effect of the compound salvia miltiorrhiza injection in adjuvant therapy of severe acute pancreatitis (SAP).Methods: Fifty patients with SAP were received and treated in our hospital.They were randomly divided into the control group and the treatment group.Both groups received conventional treatment,i.e.fasting,gastrointestinal decompression,expansion of blood volume,correction of electrolyte disturbances,anti-infection therapy,inhibition of pancreatic secretion,nutritional support,etc.On top of conventional treatment,the treatment group received intravenous drip of 20 ml compound salvia miltiorrhiza injection combined with 250ml 0.9% NaCl solution,once per day.Both groups received 10 days of treatment,and were observed of the changes in symptoms,signs and laboratory indexes before and after treatment.Results: 1) First defecation time,bowel sound recovery time,and abdominal tenderness disappear time of the treatment group were shorter than that of the control group,and the differences were statistically significant (P<0.05); 2) Complications rate,surgical operation rate and case fatality rate of the two groups were with statistical differences (P<0.05); 3) In the treatment group,the time of plasma endotoxin,serum amylase,the leukocyte count all returned to normal,which were better than that of the control group (P<0.05).After treatment,serum Tumor Necrosis Factor alpha (TNF alpha),interleukin-8 (IL-8) and interleukin-6 (IL-6) level of the treatment group were significantly lower than that of the control group (P<0.05).Conclusion: The application of compound salvia miltiorrhiza injection in the adjuvant therapy of SAP can promote the recovery of gastrointestinal function and reduce the incidence of complications and case fatality,thus is suggested to be further promoted in clinical practice.

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