丹红注射液治疗脑梗死患者的临床研究
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Clinical Research of Dan Hong Injection for Treatment of Cerebral Infarction
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    摘要:

    目的:观察丹红注射液对脑梗死的临床疗效并探讨其作用机制。方法:脑梗死患者202例,随机分为对照组、治疗组。对照组口服肠溶阿司匹林,静脉滴注依达拉奉+甘露醇;治疗组在此基础上加用丹红注射液;测定治疗前及治疗2周(W)后一氧化氮合成酶(NOS)及超氧化物歧化酶(SOD)含量,测定血液流变学指标并动态观测局部脑血流(rCBF),记录2组病例治疗前后神经功能缺损评分并比较其疗效。结果:丹红注射液能显著增加SOD及NOS含量,提高rCBF,神经功能缺损评分明显好转,与对照组比较均有统计学意义(P<0.05)结论:丹红注射液可降低脑梗死后脂质过氧化、具有清除氧自由基、改善局部脑血流,对脑梗死有理想的疗效。

    Abstract:

    To observe the clinical effects of Dan Hong Injection on cerebral infarction and to explore its action mechanism.Methods: A total of 202 patients with cerebral infarction were randomly divided into control group and treatment group.Control group took oral aspirin and intravenous drip in adr + mannitol; the treatment group took Dan Hong Injection in addition to abovementioned treatments; after 2 weeks (W) treatment,we measured nitric oxide synthase (NOS) and superoxide dismutase (SOD) content,determined blood rheology indicators and regional cerebral blood flow (rCBF),nerve dysfunction scoring and compared the curative effect.Results: Compared with that of the control group),Dan Hong Injection could significantly increase SOD and NOS,improve rCBF and neural function defect score.Conclusion: Dan Hong Injection can decrease the lipid peroxidation after cerebral infarction,remove oxygen free radicals,improve regional cerebral blood flow,therefore have ideal efficacy on cerebral infarction.

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祁涛,彭吉霞,刘兴林,陈德森.丹红注射液治疗脑梗死患者的临床研究[J].世界中医药,2015,10(04).

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  • 收稿日期:2014-03-07
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  • 在线发布日期: 2015-05-06
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