| 引用本文:祁涛1，彭吉霞2，刘兴林2，陈德森2.丹红注射液治疗脑梗死患者的临床研究[J].世界中医药,2015,10(04):. |
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| 丹红注射液治疗脑梗死患者的临床研究 |
| Clinical Research of Dan Hong Injection for Treatment of Cerebral Infarction |
| 投稿时间：2014-03-07 |
| DOI：10.3969/j.issn.1673-7202.2015.04.016 |
| 中文关键词: 丹红注射液 脑梗死 一氧化氮合成酶 超氧化物歧化酶 血液流变学 局部脑血流 |
| English Keywords:Dan Hong Injection Cerebral infarction Nitric oxide synthase Superoxide dismutase Hemorheology Regional cerebral blood flow |
| 基金项目: |
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| 中文摘要: |
| 目的：观察丹红注射液对脑梗死的临床疗效并探讨其作用机制。方法：脑梗死患者202例，随机分为对照组、治疗组。对照组口服肠溶阿司匹林，静脉滴注依达拉奉+甘露醇；治疗组在此基础上加用丹红注射液；测定治疗前及治疗2周（W）后一氧化氮合成酶（NOS）及超氧化物歧化酶（SOD）含量，测定血液流变学指标并动态观测局部脑血流（rCBF），记录2组病例治疗前后神经功能缺损评分并比较其疗效。结果：丹红注射液能显著增加SOD及NOS含量，提高rCBF，神经功能缺损评分明显好转，与对照组比较均有统计学意义（P<0.05）结论：丹红注射液可降低脑梗死后脂质过氧化、具有清除氧自由基、改善局部脑血流，对脑梗死有理想的疗效。 |
| English Summary: |
| To observe the clinical effects of Dan Hong Injection on cerebral infarction and to explore its action mechanism.Methods: A total of 202 patients with cerebral infarction were randomly divided into control group and treatment group.Control group took oral aspirin and intravenous drip in adr + mannitol; the treatment group took Dan Hong Injection in addition to abovementioned treatments; after 2 weeks (W) treatment,we measured nitric oxide synthase (NOS) and superoxide dismutase (SOD) content,determined blood rheology indicators and regional cerebral blood flow (rCBF),nerve dysfunction scoring and compared the curative effect.Results: Compared with that of the control group),Dan Hong Injection could significantly increase SOD and NOS,improve rCBF and neural function defect score.Conclusion: Dan Hong Injection can decrease the lipid peroxidation after cerebral infarction,remove oxygen free radicals,improve regional cerebral blood flow,therefore have ideal efficacy on cerebral infarction. |
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