Bupleurum is mainly used in the chapter of Shaoyang disease in the , and it is increased and decreased on the base of the minor Bupleurum decoction, including six decoction: minor Bupleurum decoction, major Bupleurum decoction, Radix Bupleuri decoction plus marabilite, Bupleurum decoction with Guizhi, Bupleurum guizhi decoction with dried ginger and Bupleurum Longgu oyster decoction. This article discusses each prescription and clinical application through summarizing the application of Bupleurum in the .Because Shaoyang meridian is the manifestations of half exterior and half interior, as the cardinal of three yin meridians and three yang meridians, Bupleurum decoction has the function of relieving Shaoyang, dredging and regulating activities of collaterals of the whole body, and its clinical application is very extensive. In the clinical syndrome differentiation and treatment, we should be careful when scrutinizing its pathogenesis and primary symptoms, grasp the pathogenesis to obtain good effect.