To establish quality representation and correlation analysis on Chaihu (Bupleuri Radix) based on the quality evaluation model of drug system.Methods:Use HPLC method to simultaneously determine the 4 effective index components of Chaihu, including rutin, saikosaponin c, a, and d, meanwhile characterize the main contents of flavonoids and saponins. Use visible spectrophotometry to determine the content of total phenolic in Chaihu.Results:Based on the quality evaluation model of drug system to characterize and correlation analysis the effective indicator ingredients and the relative ratio of them. Then evaluate the associate degree of pieces of different batches and the reference piece. The result shows the total content of effective index components in No. 7, No. 8, No. 14 is higher than No. 5 and No. 6 is closer to No. 5. No. 7, No. 8, No. 13 No. 14 have high associate degree with No.5.Comprehensive quality characterization and correlation analysis results, the No.7, No.8, No.14, No.5, No.13 have high quality ranking.Conclusion:Quality representation and correlation analysis of Chaihu are based on a new quality evaluation model of drug system. Considering quality representation based on the content and the content relative ratio of effective index components comprehensively. This paper reports the specific applications of a new way of thinking model for the quality representation and evaluation of Chaihu, providing the foundation of raw material quality control and application screening.