To review the analgesic mechanism of Chinese medicine.Methods: The regulation of beta-endorphin(β-EP),5-hydroxytryptamine (5-HT),prostaglandin2 (PGE2),nitric oxide (NO) and so on in central nervous system and peripheral nervous system were analyzed and concluded based on the recent five years’ studies from home and abroad.Results: Analgesic effect played through the central nervous system was effected by increasing the content of endogenous analgesic substances like opioid peptide,cutting down the second messenger of neurotransmitter like NO,reducing the content of PGE2 in brain tissue and raising the content of the central 5-HT; analgesic effect played through the peripheral nervous system was effected by reducing the peripheral algogenic substance and inducing pain caused by the secretion of pain,inducing the accumulation of part algogenic substance,increasing the releasing peripheral endogenous analgesia material and adjusting the c-fos gene.Conclusion: Basic research should be conducted to do further study.