Oxidized low-density lipoprotein (Ox-LDL) plays an important role in the formation of atherosclerosis (AS). It induces endothelial cell injury and aggravates AS by stimulating the relevant receptors, secreting cytokine and so on. In recent years, there are more and more reports about the antioxidant effect of Chinese medicine monomer in preventing and treating AS by reducing endothelial cell injury. This paper gives a summary review of some researches on the relationship between Ox-LDL and cardiovascular disease in recent years.