世界中医药

目的:观察调肝理脾法治疗腹泻型肠易激综合征(IBS-D)的临床疗效。方法:97例IBS-D患者随机分为调肝理脾中药组和匹维溴铵西药组,分别给予调肝理脾方及匹维溴铵治疗。疗程均为4周,疗程结束后随访3个月,观察症状疗效。结果:治疗2周后、治疗4周后、治疗结束后第1个月及第3个月随访时,2组总症状积分改善明显优于治疗前,差异有统计学意义(P<0.05);治疗4周后,2组病例IBS症状积分减少值,调肝理脾组优于匹维溴铵组,差异有统计学意义(P<0.05);治疗4周后,调肝理脾组总有效率为92.2%,匹维溴铵组为69.6%,调肝理脾组优于匹维溴铵组,差异具有统计学意义(P<0.05);在改善排便次数和大便性状等主要症状方面调肝理脾组要优于匹维溴铵组,差异有统计学意义(P<0.05)。结论:应用调肝理脾方随证加减治疗IBS-D具有较好的临床疗效。

English Summary:

To observe the clinical efficacy of the method of regulating liver and spleen on treating irritable bowel syndrome of diarrhea pattern. Methods:A total of 97 IBS-D patients were randomly divided into two groups. One group received traditional Chinese medicine treatment which has effect of regulating liver and spleen; and the other group received pinaverium bromide. Both groups received the treatment for 4 weeks. We followed up the patients for 3 months after treatment to observe the symptoms and the curative effect. Results: The symptoms of both groups showed obvious improvement than before the treatment when it was observed after 2 weeks and 4 weeks of treatment, and 1 month and 3 months after treatment. There were statistical differences (P<0.05). After 4 weeks of treatment, the symptom reduction value of regulating liver and spleen group was better than that of pinaverium bromide group with statistically significant difference (P<0.05); the total effectiveness of the regulating liver and spleen group was 92.2% and pinaverium bromide group was 69.6%, it indicated that regulating liver and spleen group was better than the pinaverium bromide group and the difference was statistically significant (P<0.05). In the respect of improving the major symptoms such as the number of defecation and character of stool, the regulating liver and spleen group was superior than pinaverium bromide group, and the difference was statistically significant (P<0.05). Conclusion:The prescription of regulating liver and spleen has a good clinical curative effect on treating IBS-D.

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