To observe the curative effect of Wuzi Yanzong Wan and Guizhi Fuling capsule combined with laparoscope in the treatment of varicocele patients. Methods: A total of 70 cases of varicocele patients were divided into laparoscopic operation group and comprehensive treatment group (which took Wuzi Yanzong Wan and Guizhi Fuling Wan for 3 months after laparoscopic operation), with 35 cases in each group. Besides, semen routine testes were given to both groups before and after treatment in 6 months. Follow-up investigation focused on pregnancy situation. Results: The results show that the sperm quantity, semen activity and normal sperm morphology rate had improved obviously in patients of both groups. Moreover, semen density, semen survival rate, semen activity and normal morphology sperm of the comprehensive treatment group appear notable difference to the control group, with P<0.05. Conclusion: Combination of Wuzi Yanzong Wan and Guizhi Fuling capsule with laparoscope can significantly improve the condition of varicocele in infertile men.