| 引用本文:袁玉娇，占戈，田园.C反应蛋白与高血压病中医辨证分型、靶器官损害相关性的研究[J].世界中医药,2015,10(05):. |
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| C反应蛋白与高血压病中医辨证分型、靶器官损害相关性的研究 |
| Research of Correspondence among Hypertension Types Based on Traditional Chinese Medicine Pattern Differentiation, C-reactive Protein and Target Organ Damage |
| 投稿时间：2015-03-09 |
| DOI：10.3969/j.issn.1673-7202.2015.05.024 |
| 中文关键词: C反应蛋白 高血压病 中医证型 靶器官损害 |
| English Keywords:CPR Hypertension TCM pattern Target organ damage |
| 基金项目:北京市中医药科技项目（编号：JJ2012-58） |
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| 中文摘要: |
| 目的：通过对高血压病患者血清C反应蛋白(CRP)的测定，探讨其与中医辨证分型、靶器官损害的相关性。方法：根据《中国高血压防治指南》和本研究设定纳入、排除标准，选择原发性高血压患者308例，并参照《中药新药治疗高血压病的临床研究指导原则》进行中医辨证分型，分为肝火亢盛型、痰湿壅盛型、阴虚阳亢型、阴阳两虚型。抽取患者空腹静脉血，测定血清CRP。同时收集受试者高血压相关临床资料，运用SPSS 22.0统计分析软件对资料进行统计分析。结果：1）C反应蛋白与高血压分级及危险分层的关系：CRP水平随着高血压分级水平的升高而呈上升趋势，但各组比较无明显统计学意义（P>0.05）。CRP水平随着危险分层的升高逐渐升高(P<0.05)。2）C反应蛋白与心脑血管危险因素及靶器官损害的内在联系：1)CRP水平与患者腹型肥胖、吸烟等心血管病的危险因素无相关性(P>0.05)。2）在心脏、脑、血管、肾等靶器官损害组，其CRP水平高于无靶器官损害组(P<0.05)。3）C反应蛋白与高血压中医辨证分型的相关性：CRP水平随证型的演变而变化，具体为痰湿壅盛型组>阴虚阳亢型组>阴阳两虚型组>肝火亢盛型(P<0.05)。4）高血压中医辨证分型与靶器官损害的联系：肝火亢盛型组、阴虚阳亢型组以脑损害为主，痰湿壅盛型组以血管损害为主，阴阳两虚型组则心脏、肾损害为主。结论：高血压患者CRP水平不仅与危险分层以及靶器官损害情况相关，而且与高血压中医证型存在相关性，同时不同中医证型出现不同的靶器官损害。 |
| English Summary: |
| To observe the correspondence among Traditional Chinese Medicine (TCM) pattern differentiation and C-reactive protein and target organ damage. Methods: 308 cases of patients with primary hypertension were chosen based on “the Guidelines for Prevention and Control of Hypertension” and inclusion criteria of this research. According to “the Guidelines of New TCM Drugs in the Clinical Research of Hypertension”, all patients were categorized into TCM pattern types, namely, intensive liver fire pattern, congested phlegm-dampness pattern, yin deficiency with yang hyperactivity pattern and deficiency of both yin and yang pattern. Moreover, fasting venous blood samples of all patients were taken for a CRP test. Meanwhile, clinical record of these patients were collected to analyze through the software of SPSS 22.0. Results: 1) The correlation between CPR and hypertension risk classification and stratification: The higher the level of hypertension risk, the higher the level of CPR was. However, the result is of no statistical significance (P>0.05). Also, the level of CPR rose along with the level of risk stratification of hypertension, and the result is of statistical significance. (P<0.05) 2) The correlation between CPR,cardiovascular risk factors and target organ damage: a. CPR was not related to cardiovascular risk factors such as abdominal obesity and smoking. (P>0.05). b. The CPR level of target organ (heart, brain, blood vessel and kidney) damage group was higher than the group without target damage group. 3) The relation between CPR and TCM pattern differentiation: the CPR level correlates with different pattern types. To be specific, the levels of CPR were higher than the other in such an order: congested phlegm-dampness pattern>yin deficiency with yang hyperactivity pattern>deficiency of both yin and yang pattern>intensive liver fire pattern. (P<0.05) 4) The relation between different TCM patterns and target organ damage : patients with intensive liver fire pattern and yin deficiency with yang hyperactivity pattern were mainly suffered from brain damage, patients with congested phlegm-dampness pattern from blood vessel damage, and patients with deficiency of both yin and yang pattern from heart and kidney damage. Conclusion: The CPR level, target organ damage and hypertension of TCM pattern correlates with each other. In other words, different TCM pattern types of hypertension patients suffers from different target organ damage. |
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