| 引用本文:王敏，许永崧，龚慕辛，贾富霞，任维，赵香妍.不同双黄膏剂体外扩散的实验研究[J].世界中医药,2015,10(05):. |
|
| 不同双黄膏剂体外扩散的实验研究 |
| Experimental Studies of Different Shanghuang Ointment on Transdermal Diffusion in Vitro |
| 投稿时间：2014-04-26 |
| DOI：10.3969/j.issn.1673-7202.2015.05.033 |
| 中文关键词: 黄芩苷 双黄膏 凝胶 蛇蜕 小鼠腹皮 经皮扩散 冰片 |
| English Keywords:Baicalin Carbomer gel Shanghuang ointment Snake slough Mice abdomen skin Percutaneous diffusion Borneol |
| 基金项目: |
|
| 摘要点击次数: 1200 |
| 全文下载次数: 1355 |
| 中文摘要: |
| 目的：研究3种双黄膏剂中黄芩苷在蛇蜕、小鼠腹皮的经皮扩散情况并对结果进行分析比较。方法：使用智能透皮试验仪对双黄冰凝胶（A）、双黄冰乳膏（B）、双黄乳膏（C）3种膏剂进行体外经皮扩散实验，测定黄芩苷的累积透过量和经皮扩散速率。结果：小鼠腹皮的累积透过量及经皮扩散速率均明显高于蛇蜕（P<0.01）。对于蛇蜕，各时间点A的累积透过量及经皮扩散率高于B、C（P<0.01），而B与C相比差异无统计学意义；对于小鼠腹皮，3种软膏累积透过量和经皮扩散率均无统计学意义。结论：采用不同皮肤会造成实验结果的不同。对于可增加角质层水合作用的凝胶剂，蛇蜕灵敏度高，干扰因素少，结果稳定。 |
| English Summary: |
| To study the transdermal diffusion of baicalin in three Shanghuang Ointment and compare the effect of different skin and ointment bases on diffusion. Methods: Intelligent transdermal test instrument was used to determine the cumulative permeating amounts of baicalin from Shanghuang Carbomer gel（A）, Shanghuang Cream with borneol（B）and without borneol（C）.Then diffusion rate could be calculated. Results: the cumulative permeating amounts and transdermal diffusion rate on mice abdomen skin were significantly higher than those on snake slough（P<0.01）. On snake slough, the cumulative permeating amounts and transdermal diffusion rate of baicalin in cream A was significantly higher than cream B and C（P<0.01，0.01）. The difference of the cumulative permeating amounts between two creams was not significant on mice skin. Conclusion: Different skin will make the different outcome. Shanghuang Carbomer gel can soften cuticles, and snake slough is superior to mice skin because of its high sensitivity, less interferences and excellent stability. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
