世界中医药

作者	单位
贾冕1，赵进喜2，董超3，封然1，伍鋆1	1 北京中医药大学第一临床医学院内分泌科,北京,100700 2 北京中医药大学东直门医院中医内科教研室,北京,100700 3 北京市第一中西医结合医院内分泌科,北京,100026

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中文摘要:

目的:在理论研究及临床实践的基础上,观察三黄益肾颗粒对气阴两虚、血瘀湿浊证的糖尿病肾病IV期患者的治疗效果。方法:使用中药三黄益肾颗粒和西药厄贝沙坦,基于糖尿病肾病IV期患者,进行多中心随机对照研究。结果:研究纳入病例56例,治疗组27例,对照组29例。2组均可改善中医证候总积分(P<0.01),治疗组优于对照组;治疗组可显著改善24 h尿蛋白定量(P<0.05),综合疗效评定有效率92.6%,优于对照组(P<0.01)。2组试验过程中未发现任何不良反应。结论:基于益气养阴化瘀泄浊治法的三黄益肾颗粒可缓解临床症状,明显减少中医证候积分,减少24 h尿蛋白定量,综合疗效优于对照组。

English Summary:

To observe the curative effect of Sanhuang Yishen Granule in treating diabetic nephropathy patients in stage IV who have the syndromes of dual deficiency of qi and yin and blood stasis and dampness. Methods: A multi-center randomized controlled study was conducted on patients with diabetic nephropathy in phase IV. Sanhuang Yishen Granule and Irbesartan placebo were given to the treatment group and Sanhuang Yishen Granule and Irbesartan to the control group. A total of 56 cases were divided as 27 in the treatment group and 29 in the comparison group. Results: TCM syndromes total score in both of the two groups were improved and the treatment group performed better than the control group (P<0.01). The 24 hour urine protein quantity in the treatment group was significantly improved (P<0.05), with the comprehensive evaluation of curative effect rate of 92.6%, which was also higher than that of the control group (P<0.01). No adverse reaction was found in both groups. The comprehensive curative effect of the treatment group is better than the control group. Conclusion: By replenishing qi and nourishing yin and removing blood stasis and discharging turbidity, Sanhuang Yishen Granule can relieve clinical symptoms, reduce the TCM syndrome scores and the 24 hour urine protein quantity.

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