| 引用本文:张凯辉1，段行武2.“消银解毒饮”对银屑病血热证外周血淋巴细胞调控作用研究[J].世界中医药,2015,10(06):. |
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| “消银解毒饮”对银屑病血热证外周血淋巴细胞调控作用研究 |
| Study on Regulation Role of Xiaoyinjiedu Drink on Peripheral Blood T-lymphocytes in Blood-heat Syndrome of Psoriasis Patients |
| 投稿时间：2014-11-04 |
| DOI：10.3969/j.issn.1673-7202.2015.06.015 |
| 中文关键词: 消银解毒饮 银屑病血热证 T淋巴细胞 共刺激因子 |
| English Keywords:Xiaoyinjiedu Drink Blood-heat Syndrome of Ps T-lymphocytes Co-stimulatory factor |
| 基金项目:国家自然科学基金项目(编号：81273755)——新型T辅助细胞亚群Th17、Th22及效应因子IL-22与银屑病辨证论治关系的研究 |
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| 中文摘要: |
| 目的：观察正常人及银屑病患者应用消银解毒饮治疗前后外周血T淋巴细胞及共刺激因子表达的变化，探讨“消银解毒饮”对银屑病血热证外周血淋巴细胞调控作用。方法：治疗组给予连续8周消银解毒饮治疗，用流式细胞术检测，与对照组相互比较外周血T细胞亚群及共同刺激分子CD28、CD80、CD86的表达情况。结果：治疗组治疗后皮损评分降低；治疗前后与正常人相比CD3+、CD4+细胞及CD4+/CD8+降低，CD8+细胞升高；CD28疗前高于、疗后低于正常组；CD86治疗前后均明显高于正常组；CD80正常组与治疗前均无明显统计学意义，治疗后有下降的趋势。治疗组治疗前、后外周血T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+和共刺激因子CD28、CD80、CD86均无明显的统计学意义。结论：消银解毒饮临床疗效肯定；银屑病患者外周血T细胞亚群及共刺激因子的表达存在异常；患者临床症状的好转与外周血T细胞亚群及共刺激因子表达的改变是否平行相关尚不确定。 |
| English Summary: |
| 〓To explore the regulation role of Xiaoyinjiedu drink on peripheral blood T-lymphocytes in blood-heat syndrome of Ps(Psoriasis) patients by observing peripheral blood T lymphocytes and the expression of co-stimulatory factor changes of normal and Psoriasis patients, who received Xiaoyinjiedu Drink.Methods:Treatment group was given 8 weeks of medication, using flow cytometry, while comparison was made to the control group in terms of Peripheral Blood T-lymphocytes and Co-stimulatory factor CD28, CD80, CD86.Results:The treatment groups lesion scores decreased after treatment; CD3+, CD4+and CD4+/CD8+ is reduced when compared with normal group before and after treatment; CD28 was higher than the normal group before treatment, but lower than normal group after treatment; CD86 was significantly higher than the normal group before and after treatment; There was no significant difference between the normal group and treatment before, but after treatment there was a downward trend in CD80. There was no significant difference in the peripheral T-lymphocytes CD3+, CD4+, CD8+, CD4+/CD8+ and Co-stimulatory factor CD28, CD80, CD86 before and after treatment in the treatment group.Conclusion:Xiaoyinjiedu Drink has positive clinical effect. Psoriasis patients peripheral blood T-lymphocytes and Co-stimulatory factor have abnormal expression. It is uncertain whether the improvement of clinical symptoms of patients and the expression of T-lymphocytes and Co-stimulatory factor are parallel related. |
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