| 引用本文:孙欣1，尹宏2，卞勇1，钱卫庆2.活血散对大鼠急性软组织损伤PGE2及IL-6影响的实验研究[J].世界中医药,2015,10(06):. |
|
| 活血散对大鼠急性软组织损伤PGE2及IL-6影响的实验研究 |
| Effect of Huoxuesan on PGE2 and IL-6 in the Treatment of Rat Acute Soft Tissue Injury |
| 投稿时间：2015-04-30 |
| DOI：10.3969/j.issn.1673-7202.2015.06.025 |
| 中文关键词: 活血散 软组织损伤 实验 大鼠 PGE2 IL-6 |
| English Keywords:Huoxuesan Soft tissue injuries Experiment Rats PGE2 IL-6 |
| 基金项目:国家自然科学基金项目(编号:31360629) |
|
| 摘要点击次数: 1421 |
| 全文下载次数: 1542 |
| 中文摘要: |
| 目的:观察活血散对大鼠急性软组织损伤模型血清PGE2及IL-6影响,初步探讨其干预软组织损伤模型修复的可能机制。方法:造模后,随机分组,给予相应药物,动态观察大鼠损伤症候指数评分、组织形态学指标,并测量大鼠血清中PGE2、IL-6含量,进行统计学分析。结果:活血散软膏组在损伤症候指数、组织形态学方面优于模型组。活血散软膏可降低大鼠血清中PGE2、IL-6含量。结论:活血散软膏具有消肿、止痛、抗炎、促进软组织肌纤维修复的作用,其作用发生机制可能与抑制损伤局部组织中的PGE2、IL-6含量升高有关。 |
| English Summary: |
| To observe the effect of Huoxuesan on PGE2 and IL-6 level in rats with acute soft tissue injury so as to explore the possible mechanism of Huoxuesan in restoring soft tissue damage. Methods: After modeling, rats were randomized into two groups and given different drugs. Dynamic observation was conducted on the aspects of injury symptom index, histomorphology index, and serum level of PGE and IL-6 respectively, followed by statistical analysis. Results: The group used Huoxuesan performs better in injury symptom score and histomorphology score. Huoxuesan can also lower the levels of PGE2 and IL-6 in rats serum. Conclusion: Huoxuesan can diminish inflammation and swelling and relieve pain. It can also contribute to the restore of soft issue. This may due to its determent on the levels of PGE2 and IL-6. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
