世界中医药

目的:对近10年治疗肿瘤放化疗后白细胞减少的用药进行回顾性分析,为临床选方用药提供依据和思路。方法:收集整理2004—2013年中国期刊全文数据库、中国生物医学文献数据库、万方数据库收录的有关中医或中西医结合治疗肿瘤放化疗后白细胞减少的方药记载文献。参照《中华人民共和国药典》和《中药学》的专业术语为标准,应用SPSS 13.0统计学软件对文献资料的单味药频次、药物功效、中药性味归经进行分类统计。结果:检索到相关文献103篇,涉及114首复方、148味中药、18类药。单味药使用总频次是1 229次,以补虚药(66.4%)、活血化瘀药(7.16%)、消食药(5.04%)为主,其中黄芪使用频次最多,为91次,占79.8%;药性以温、平、寒药为主,温性药占52.5%;药味多为甘、苦、辛,甘味药占52.7%;药物归经以脾经、肝经、肾经为主。结论:肿瘤放化疗后白细胞减少的治疗原则多以扶正为本,重在补益气血,调理脾、肝、肾,黄芪为常用治疗药物,基本贯穿于治疗始末。

English Summary:

To analyze retrospectively the medications for leukopenia after radio-chemotherapy in cancer treated in recent decade years so as to provide the evidence and approaches to the application of Chinese medicine in clinic.Methods:The literatures on Chinese medicine formulas were collected from Chinese Journal Full-text Database and Chinese Biological Medicine on Disc and Wanfang Database in terms of the treatment of leukopenia after radio-chemotherapy in cancer with traditional Chinese medicine or integrated Chinese and western medicine from year 2004 to 2013. In reference to the standard terminology in Pharmacopoeia of the Peoples Republic of Chinese and Chinese Materia mMdica, using SPSS13.0 statistical software, the usage frequency of single herb, drug efficacy and nature, flavor and channel tropism of Chinese herbs were classified and analyzed statistically.Results:One hundred and three relevant literatures were retrieved, among which, there were 114 Chinese herbal formulas, 148 different herbs and 18 categories of Chinese herbal medicine. The total frequency of single herb was 1229 times. Among those different herbs, 66.4% of them were in the category of replenishing the deficiency, 7.16% of them were of activating blood circulation and resolving stasis and 5.04% of them were of promoting digestion. Astragalus membranaceus was on the top in usage frequency, totally 91 times, accounting for 79.8%. Regarding the nature of Chinese herbal medicine, the warm, neutral and cold natures were predominated, in which, those of warm nature accounted for 52.5%. Regarding to the flavor, sweet, bitter and pungent flavors were predominated, in which, those of sweet flavor accounted for 52.7%. Regarding to channel tropism, spleen, liver and kidney channels were mainly involved.Conclusion:In the treatment of leukopenia after radio-chemotherapy in cancer, strengthening the antipathogenic qi is the root, also it requires focusing on tonifying qi and blood, and regulating the functions of spleen, liver and kidney. Astragalus membranaceus is the common herb in the entire process of treatment.

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