| 引用本文:盛环良1，常诚2.大黄改善认知功能研究进展[J].世界中医药,2015,10(06):. |
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| 大黄改善认知功能研究进展 |
| Review of Research Progress on Rhubarbs Efficacy in Improving Cognitive Function |
| 投稿时间：2014-12-24 |
| DOI：10.3969/j.issn.1673-7202.2015.06.039 |
| 中文关键词: 大黄 认知功能 老年性痴呆 毒损脑络 通腑降浊 |
| English Keywords:Rhubarb Cognitive function Senile dementia brain collateral damage due to toxin Relaxing bowels and reduce turbid |
| 基金项目:江苏省六大高峰人才资助项目（编号:2013WS-034） |
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| 中文摘要: |
| 认知功能减退作为临床症状，主要属血管性认知功能障碍（VCI）和阿尔兹海默病（AD）范畴。中医对痴呆的病机认识，认为“脑消髓减”为疾病基础，“痰瘀阻络”为标，近年更发展痴呆的“毒损脑络”的病机。大黄具有“以通为补”的作用,并能通腑降浊、活血祛瘀、清热解毒，能针对痴呆“脑消髓减、痰瘀阻络、毒损脑络”的病机，可以很好的运用于认知功能的改善。近年对大黄成分的药理研究表明大黄抗氧化作用较为突出，具有抗衰老作用，能改善老年人的认知功能。同时，对大黄“荡涤肠胃”的作用研究显示，确有“推陈致新”的作用，减少体内肠源性内毒素的集聚，对认知功能有改善作用。 |
| English Summary: |
| As a clinical symptom, cognitive impairment belongs to vascular cognitive impairment (VCI) or Alzheimers Disease (AD). Traditional Chinese Medicine(TCM) regards that “brain and marrow insufficiency” is the root cause and “collateral obstruction by phlegm” is the manifestation for dementia. Recent studies regard that “brain collateral damage due to toxin” is the mechanism of dementia. TCM believes that Rhubarb can tonify the body by removing stasis, and can relax bowels and reduce turbid, activate blood and remove stasis, and clear heat and expel toxin, and thus to be used in treating dementia. Recent pharmacology studies suggest that Rhubarb excel in antioxidant and anti-aging, which can be used to improve the cognitive function of elder people. Also, studies on Rhubarbs function to clear turbid in intestine showed that it can remove stasis and promote regeneration, especially eliminate enterogenous endotoxin. Consequently, it can contribute to the improvement of cognitive function. |
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