| 引用本文:薛红，张北华，王凤云，唐旭东.中药复方改善腹泻型肠易激综合征内脏高敏感作用机制探讨[J].世界中医药,2015,10(07):. |
|
| 中药复方改善腹泻型肠易激综合征内脏高敏感作用机制探讨 |
| Investigation of Improving Visceral Hypersensitivity of Diarrhea Predominant Irritable Bowel Syndrome (IBS-D) Treated by Chinese Herbal Compound and Mechanism |
| 投稿时间：2015-06-24 |
| DOI：10.3969/j.issn.1673-7202.2015.07.002 |
| 中文关键词: 肠易激综合征 内脏高敏感 基础研究 机制 |
| English Keywords:Irritable bowel syndrome Visceral hypersensitivity Basic research Mechanism |
| 基金项目:国家重点基础研究发展计划资助项目(编号：2013CB531703);国家自然科学基金资助项目(编号：81173209) |
|
| 摘要点击次数: 1311 |
| 全文下载次数: 1774 |
| 中文摘要: |
| 目的：近年来中药在治疗（IBS-D）的临床和实验研究中取得了较大进展，作者对中药治疗本病的机理进行综述。方法：查阅近5年的国内外文献，从中药调节腹泻型肠易激综合征的脑肠胺（肽）及神经递质表达，含量及相关炎性因子改变等进行归纳、分析、总结。结果：中药治疗腹泻型肠易激综合征的主要途径包括降低血中和结肠黏膜中5-HT浓度和含量，减少血管活性肠肽(VIP)表达及分泌，升高肠组织中NO水平，降低血浆中胃动素(MOT)，胰高血糖素样肽-1(GLP-1)，生长抑素(SS)，P物质(SP)的含量。神经免疫机制包括减少肥大细胞数目及活化，调节促炎因子\抗炎因子水平。结论：应进一步加强中药复方改善腹泻型肠易激综合征作用机制研究，为解释中药科学内涵及进一步开发提供参考。 |
| English Summary: |
| In recent years, traditional Chinese medicine has made great progress in the treatment of diarrhea predominant irritable bowel syndrome (IBS-D) in clinical and experimental research. In this paper, the mechanism of traditional Chinese medicine treatment of this disease was summarized. Methods:The impact of traditional Chinese medicine (TCM) on the brain gut amine (peptide) and neurotransmitter expression, the content and related inflammatory factor change were our major interests when conducting literature review on published literature home and abroad in recent five years. Results:The main mechanism of TCM is：lowering the content of 5-HT in colonic mucosa and blood, reducing the expression of vasoactive intestinal peptide (VIP) and secretion, increasing the NO level in the intestinal tissue, reducing gastric dynamic element (MOT) in plasma, glucagon like peptide 1 (glp-1) and somatostatin (SS), the content of substance P (SP), reducing the number of mast cells and nerve immunity mechanism activation, regulation of pro-inflammatory factor and anti-inflammatory factor levels. Conclusion:The mechanism research should be further enhanced to reveal the physiological and pathological mechanism of TCM treatment. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
