| To observe the efficacy of tonifying Kidney-yin and fire-clearing prescription in treating polycystic ovary syndrome (PCOS) with high testosterone. Methods:Thirty patients with PCOS accompanied high testosterone were recruited and treated with Zhibai Dihuang Formula for 3 months. The efficacy was evaluated after treatment. The serum testosterone (T) and follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2), prolactin (PRL), Fasting insulin (FINS), the scores of menstruation, the scores of TCM symptoms, the scores of acne, the basal body temperature (BBT), the volume of ovarian, routine blood test, alanine aminotransferase (ALT), creatinine (CR) and urea nitrogen (BUN) were compared between before and after treatment. Results: 3 months later, the serum testosterone level，the scores of menstruation, the scores of TCM symptoms and the scores of acne were lower after treatment than that of before treatment (P<0.01; P<0.05＝. 46.7% of the patients manifested bipolar order on basal body temperature, but FSH, LH, E2, PRL, FINS, the volume of ovarian, routine blood test, ALT, CR and BUN had no obvious change(P>0.05). Conclusion: Tonifying kidney-yin and clearing fire method proved efficient on lowering serum T, improving the clinical manifestations of hyperandrogenism of PCOS, and promoting patients recovery of spontaneous ovulation. |
