Abstract:Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorders in reproductive age women. About 70% of PCOS patients have abnormal lipid metabolisms, which increases the risk of suffering from cardiovascular diseases. This has pose a threat to their life and health. The possible pathogenesis may relate to the abnormal expression of ApoA1, the regulation factors of lipid metabolism, adiponectin, leptin, visfatin and corresponding genes. However, currently, there are in lack of drugs and instruments for the targeted treatment of PCOS with abnormal lipid metabolisms. Previous studies have confirmed that Traditional Chinese Medicine is effective to improve the conditions of abnormal lipid metabolisms in patients with PCOS, which has the effects of multi-target, multi-link, and multi-channel. Furthermore, it can also improve the endocrine and metabolic disorders in patients with PCOS with a relatively dafe approach. It is significant to carry out the mechanism researches to observe the effects of Traditional Chinese Medicine on PCOS with abnormal lipid metabolism by the method of metabolomics, which will provide scientific basis for the popularization of Traditional Chinese Medicine for the treatment of PCOS with abnormal lipid metabolism.