| 引用本文:周平1，罗云2，邢娜3，卢珊2，孙桂波2，孙晓波2.肿瘤坏死因子α介导动脉粥样硬化发生机制的研究进展[J].世界中医药,2015,10(08):. |
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| 肿瘤坏死因子α介导动脉粥样硬化发生机制的研究进展 |
| Research Progress of Pathogenesis of Atherosclerosis Induced by Tumor Necrosis Factorα |
| 投稿时间：2015-06-29 |
| DOI：10.3969/j.issn.1673-7202.2015.08.008 |
| 中文关键词: 肿瘤坏死因子α 动脉粥样硬化 发生机制 |
| English Keywords:Atherosclerosis Tumor necrosis factor alpha Pathogenesis |
| 基金项目:国家科技重大专项课题，重大新药创制基金(编号：2012ZX09501001-004)；哈尔滨商业大学研究生创新项目(编号：YJSCX2014-324HSD) |
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| 中文摘要: |
| 动脉粥样硬化作为一种复杂的炎症性疾病，已严重威胁人类健康。肿瘤坏死因子α是一种多效性的细胞因子，可通过多种信号通路介导炎症反应。大量研究表明，肿瘤坏死因子α能够诱导血管内皮细胞、血管平滑肌细胞的损伤，诱导单核细胞的迁移并与内皮细胞黏附以及泡沫细胞的形成，同时还能影响斑块的稳定性，深度参与动脉粥样硬化的形成和发展。文章就近年来肿瘤坏死因子α介导动脉粥样硬化发生机制的研究予以综述。 |
| English Summary: |
| Atherosclerosis, which is the main consequence of a complicated inflammatory process, has threatened human health seriously. Tumor necrosis factor alpha is a multifunctional cytokine which is regarded to mediate the inflammatory response by activating various signaling pathways. A large number of studies showed that tumor necrosis factor alpha could not only induce the injure of vascular endothelial cells and vascular smooth muscle cells, but also induced the migration of monocytes and endothelial cell adhesion and foam cell formation. At the same time, the stability of the plaque may also be affected, tumor necrosis factor alpha crucially involved in the pathogenesis and progression of atherosclerosis. This article made a review on the studies researched on pathogenesis of atherosclerosis due to tumor necrosis factor alpha. |
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