The lung and large intestine are interior-exteriorly related. The two interrelated in physiology and mutually influential in pathology. Clinical treatment is common to see lung disease treating from bowel, bowel disease treating from lung, and simultaneous treatment on both lung and intestine. In so many treatment, regulating qi activity of lung and large intestine is necessary. From the perspective of Qi activity, this paper explored the theoretical connotation of the lung and the large intestine Qi activity, put forward the idea of treating lung and intestine diseases should meet the lifting Qi characteristics of the lung and the large intestine, maintain the relationship of Qi activities between lung and the large intestine, and mobilize the inherent power of two lifting for the fundamental treatment.