| 引用本文:李蓉.黄芪注射液联合布地奈德雾化吸入治疗支气管哮喘疗效及对患者肺功能和炎性因子的影响[J].世界中医药,2015,10(08):. |
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| 黄芪注射液联合布地奈德雾化吸入治疗支气管哮喘疗效及对患者肺功能和炎性因子的影响 |
| Efficacy of Astrag Alus Injection Combined with Budesonid Inhaling and Its Influence on Pulmonary Function and Inflation Factors in Bronchial Asthma Patients |
| 投稿时间：2014-09-19 |
| DOI：10.3969/j.issn.1673-7202.2015.08.017 |
| 中文关键词: 黄芪注射液 布地奈德 支气管哮喘 |
| English Keywords:Astragalus injection Budesonid Bronchial asthma |
| 基金项目:四川省遂宁市卫生局资助项目(编号:sn291823) |
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| 中文摘要: |
| 目的:探讨黄芪注射液联合布地奈德雾化吸入治疗支气管哮喘的疗效及其临床价值,为临床治疗该病提供相应依据。方法:2010年6月至2013年6月在我院诊治的94例支气管哮喘患者作为研究对象。随机分为对照组47例和治疗组47例,对照组在常规治疗基础上给予布地奈德雾化吸入治疗;治疗组在常规治疗上给予黄芪注射液联合布地奈德雾化吸入治疗。比较2组患者疗效、肺功能指标及IL-6、IL-10及IL17等炎性因子水平。结果:对照组47例患者,治疗有效率为83.0%;治疗组47例,治疗有效率为97.9%,显著高于对照组,P<0.05,差异具有统计学意义。2组患者VC、FEV1及FEV1/FVC等肺功能指标、IL-6、IL-10与IL-17水平较治疗前均有所改善,P值均<0.05,差异均具有统计学意义。然而经过治疗后,治疗组患者肺功能指标及炎性细胞因子水平较对照组改善更为显著，P值均<0.05,差异均有统计学意义。结论:黄芪注射液联合布地奈德雾化吸入治疗支气管哮喘可取得较好疗效,显著改善肺功能功能、降低其血清炎性因子水平,值得在临床上进一步深入探讨研究与推广应用。 |
| English Summary: |
| To investigate the clinical efficacy of astragalus injection combined with budesonid inhaling in patients with bronchial asthma(BA)and provide clinical evidences for BA treatment. Methods: From 2010/6 to 2013/6, we collected 94 BA patients in our hospital and divided them into two groups randomly, 47 cases in control group and 47 cases in observation group. The control group were treated with conventional therapy with budesonid inhaling; the observation group were treated with conventional therapy as well as budesonid inhaling and astragalus injection. Clinical effects, pulmonary function, and levels of inflammatory factors were observed and compared. Results: The observation group had a therapeutic efficiency ratio(TER)of 97.9% which was significantly higher than the control group(83.0%), and the difference was statistically significant(P<0.05). The VC, FEV1, FEV1/FVC, and the levels of IL-6, IL-10 and IL-17 of the two groups were both significantly improved respectively after treatments(P<0.05). However, those of the observation group had greater improvement than those of the control group after treatments(P<0.05). Conclusion: As it can help promote the pulmonary function and decrease the inflation factors in serum, astragalus injection combined with budesonid inhaling for BA treatment proves to be effective, which is worthy of study and further application in clinical treatment. Our study provides new evidences for clinical therapy of BA. |
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