| 引用本文:任磊1，夏梦2，潘厚儒1，段行武1.micro RNA在银屑病中医证候研究中的应用前景[J].世界中医药,2015,10(08):. |
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| micro RNA在银屑病中医证候研究中的应用前景 |
| The Prospect of Application of MicroRNA in Traditional Chinese Medicine Syndrome Research on Psoriasis Vulgaris |
| 投稿时间：2015-05-07 |
| DOI：10.3969/j.issn.1673-7202.2015.08.035 |
| 中文关键词: microRNA 银屑病 证候 |
| English Keywords:MicroRNA Psoriasis vulgaris Syndrome |
| 基金项目:2013年国家自然科学基金项目“新型T辅助细胞亚群Th17、Th22及效应因子IL-22与银屑病辨证论治关系的研究”(编号:81273755) |
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| 中文摘要: |
| microRNA是一类内生的、长约22个核苷酸左右的非编码小分子RNA，主要通过结合其靶基因的3′UTR(非翻译区)，从而降解靶基因mRNA或抑制其蛋白翻译。microRNA通过基因切割和翻译抑制的方式直接调控基因组中30%以上的蛋白编码基因表达。银屑病以过度增殖和异常分化的角质形成细胞为显著特征，角质形成细胞的上述病理改变被认为起始于细胞免疫系统，T细胞、树突细胞和多种免疫相关细胞因子均牵涉其中。而microRNA几乎参与上述整个病理过程，并发挥重要作用。且microRNA表达的特异性和时序性与证候的动态时空特性极其相似。将microRNA引入银屑病中医证候研究，为从转录后水平阐明银屑病中医证候实质提供新的视角。 |
| English Summary: |
| MicroRNA is a small non-coding endogenous RNA molecule which is consisted of approximately 22 nucleotides. It degenerate target gene mRNA or suppress its protein translation through integration with the 3UTR of the target gene. MicroRNA regulates over 30% of protein coding genetic expression of the genome by cleavage and translation suppression. Keratinocyte cell proliferation and abnormal differentiation are the key characteristics of psoriasis, and these pathological changes are thought to originate from cell immune system. T cell, dendritic cell and multiple immune-related cell factors were all involved. MicroRNA participates in throughout the pathological process and plays an important role. MicroRNA expression specificity and sequence shows great similarity with the temporal-spatial characteristic of the syndrome. Introducing mircoRNA into psoriasis TCM syndrome research provides a new aspect to the topic through the interpretation of post-transcriptional level. |
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