To explore the main syndrome types and distribution regularities of traditional Chinese medicine(TCM)syndromes by collecting muti-center nationwide clinical data of chronic hepatitis B (ALT≥2ULN) patients. Methods： A total of 1 003 chronic hepatitis B(ALT≥2×ULN) patients were recruited. By collecting the clinical manifestations of tongue， pulse and TCM symptom index and determining the distribution frequency and constituent ratio of symptoms by quantitative evaluation， the main syndrome types and their percentages were investigated. Results： The main symptoms of chronic hepatitis B (ALT≥2ULN) were： sleepy and fatigue(84.55％)， hypochondriac pain（75.67％）， yellow urine(75.37％）， dry mouth（66.20％）， indignation(60.42％)， distension syndrome(58.33％)， bitter taste(54.24％)， anorexia(53.24％)， darkish face(51.94％)， abdomen distended(48.16％). In occasions where there are more than one syndrome， dampness-heat in the liver and gallbladder syndrome and liver stagnation and spleen deficiency syndrome had a higher incidence， and the complex syndrome of dampness-heat in the liver and gallbladder and liver stagnation and spleen deficiency was the most common complex syndrome in chronic hepatitis B (ALT≥2×ULN ). Symptoms constitute and liver function index have a significant difference between the patients with dampness-heat in the liver and gallbladder syndrome from the patients with liver stagnation and spleen deficiency syndrome. Conclusion： The core syndrome of chronic hepatitis B (ALT≥2ULN) is dampness-heat in the liver and gallbladder syndrome， liver stagnation and spleen deficiency syndrome， and the complex syndrome of damp heat in the liver and gallbladder and liver stagnation and spleen deficiency.