To study the morbidity and relevant factors of minimal hepatic encephalopathy(MHE) patients with hepatitis B virus-related cirrhosis and syndrome of qi deficiency and blood stasis. Methods： A total of 114 patients with hepatitis B virus-related cirrhosis were selected， and 100 healthy people were taken as the control group. To analyze the condition and pathogenic factors of MHE in patients with hepatitis B and of qi deficiency and blood stasis syndrome. Results： The morbidity of MHE patients with hepatitis B virus-related cirrhosis was 51.75%， and was positively correlated with TBIL level(P<0.05). The incidence of MHE hepatitis B virus-related cirrhotic patients of qi deficiency and blood stasis syndrome was also related to TBIL level(P<0.05). Conclusion： The morbidity of MHE in patients with hepatitis B virus-related cirrhosis and of qi deficiency and blood stasis syndrome， and this is related to TBIL level.