| 引用本文:曾伟平，徐孝容，柳清.真武汤对糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响[J].世界中医药,2015,10(09):. |
|
| 真武汤对糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响 |
| The Effects of Spleen-Yang Strengthening Decoction on Vascular Endothelial Growth Factor and Urinary Protein Excretion Rate in Patients With Diabetic Nephropathy |
| 投稿时间：2014-12-08 |
| DOI：10.3969/j.issn.1673-7202.2015.09.015 |
| 中文关键词: 糖尿病肾病 尿蛋白排泄率 血管内皮生长因子 真武汤 |
| English Keywords:Diabetic nephropathy Urinary protein excretion rate Vascular endothelial growth factor S Spleen-yang Strengthening Decoction |
| 基金项目:国家自然科学基金项目“基于肾阳虚体质研究少、长、壮、老肾阳盛衰的基因调控”（编号：30973690） |
|
| 摘要点击次数: 953 |
| 全文下载次数: 1116 |
| 中文摘要: |
| 目的：分析真武汤对糖尿病肾病患者血管内皮生长因子及尿蛋白排泄率的影响。方法：将本院收治的70例2型糖尿病肾病患者根据入院顺序随机分为对照组（35例）和治疗组（35例），2组患者均接受糖尿病教育、糖尿病饮食，内科口服降糖药物或者皮下注射胰岛素治疗（剂量依照患者血糖水平而设定）；合并高血压者加用硝苯地平缓释片，10～20 mg，2次/d；合并高脂血症者加服辛伐他汀，20 mg/d。治疗组在对照组基础上运用真武汤，2组均以8周为1个疗程，比较2组治疗前后蛋白尿排泄率（uAER）及VEGF蛋白和mRNA的变化。结果：1）2组经过治疗uAER均较治疗前改善，其中治疗组改善的幅度更为明显（P<0.05），说明真武汤可明显改善糖尿病肾病患者的uAER，在一定程度上抑制了糖尿病肾病病情的进展。2）经过治疗2组的VEGF蛋白和mRNA表达均有所下降，其中治疗组下降的趋势较对照组明显（P<0.05），说明联合使用中药方可以使VEGF在蛋白和基因层面上均收到抑制。3）uAER与VEGF水平呈非正态分布，使用Spearman法进行相关参数相关性分析，结果发现uAER与VEGF的表达存在正相关性。结论：真武汤可降低糖尿病肾病患者血清VEGF水平，同时降低uAER，是其保护肾功能的可能作用机制之一。 |
| English Summary: |
| To analyze the impact of Spleen-yang Strengthening Decoction on vascular endothelial growth factor and urinary protein excretion rate in patients with diabetic nephropathy.Methods：Seventy cases of patients with Type 2 Diabetic nephropathy who were received and treated in our hospital were randomly divided into the control group (35 cases) and the observation group (35 cases) according to admission order， both of the two groups received Diabetes Education， Diabetic diet， internal medicine oral hypoglycemic agents or subcutaneous injections of insulin (the dose were set according to blood glucose levels of the patients); the patients who combined with hypertension were added nifedipine sustained release tablets， 10～20 mg， 2 times/day. The patients who combined with hyperlipidemia were added Simvastatin， 20 mg/day. The observation group used Self-prepared kidney invigorating decoction on the basis of the control group. Both groups had 8 weeks for a course of treatment， urinary protein excretion rate (uAER) and the protein and mRNA change of VEGF in the two groups were compared before and after the treatment.Results：1) uAER improved in the two groups after treatment compared to before the treatment， the range of improvement in the observation group was more obvious (P<0.05). This illustrated that Self-prepared kidney invigorating decoction can obviously significantly improve uAER of the patients with diabetic nephropathy， inhibited the progression of diabetic nephropathy in a certain extent. 2) after treatment， protein and mRNA expression of VEGF in the two groups decreased， the downward trend in the observation group were more obvious than the control group (P<0.05)， illustrated the combine use of prescription could suppress the VEGF in the protein and gene levels. 3) uAER and VEGF levels were in abnormal distribution， correlation analysis were proceed on relevant parameters by the method of Spearman， the results found that uAER had positive correlation with the expression of VEGF.Conclusion：Spleen-yang Strengthening Decoction can reduce the serum VEGF level in patients with diabetic nephropathy， and can reduce uAER at the same time， which could possibly be the mechanism of action to protect renal function. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
