To learn the recent progress of metabonomics technology applied on the study of TCM syndrome. Methods： We searched on domestic and oversea database using metabonomics and syndrome as subject terms and selected articles which meet inclusion criteria. Based on the method of system evaluation， the advantage of metabonomics technology and its recent development of application on the study of TCM syndrome were introduced in terms of concept of metabonomics， TCM syndrome， relation between metabonomics and TCM syndrome. Results： By using the metabonomics technology， we could find out metabolites of different syndrome types of the same disease， and finally confirm its biochemical pathways. Conclusion： Metabonomics technology is widely applied in the study of TCM syndrome and it is expected to provide a credible analysis method for the study of syndrome essence.