The research was aim to study the relativity between different syndromes of Traditional Chinese Medicine in Reflux Esophagitis(RE) and the grade of Intra-epithelial Papillary Capillary Loop (IPCL) under the Narrow Band Imaging (NBI), and explore the clinical feasibility of TCM syndrome differentiation for assessing the prognosis of Reflux Esophagitis. Methods: Esophageal lesions and TCM syndrome differentiation of 81 patients with LA-B were examined by NBI and their correlation was analyzed. Results: The non parametric test validated the diversity between the TCM syndrome differentiation and the grade of IPCL (P<0.05). Conclusion: The TCM syndrome differentiation of RE has a bearing on IPCL under the NBI. It is viable to apply the TCM syndrome differentiation assessing the prognosis of reflux esophagitis.