To investigate the clinical effect of traditional Chinese medicine combining western medicine in treatment of early diabetic nephropathy of the aged. Methods: We selected 44 patients with early diabetic nephropathy who were diagnosed in our hospital from the 2013 September 26 to 2014 December 31. They were divided into treatment group, which received treatment of traditional Chinese medicine combining western medicine, and control group, which only had western medicine. Results: The general effective rate of treatment group was better than that of western medicine treatment group. Conclusion: The combination of traditional Chinese medicine and Western medicine for treatment of early diabetic nephropathy showed obvious curative effect, and it is worthy of clinical application.