To observe the clinical effects of Heart-Draining Decoction combined with esomeprazole in the treatment of chronic atrophic gastritis. Methods: We selected 100 patients who received treatment for chronic atrophic gastritis in our hospital from January 2012 to June 2014, and randomly divided them into treatment group and control group, 50 cases for each group. The control group was given esomeprazole and the treatment group received treatment of Heart-Draining Decoction combined with esomeprazole. Two groups were observed and compared for the clinical effects after 3 months of treatment. Results: There was no significant difference in the gastric mucosal atrophy and the intestinal metaplasia scores between the two groups before the treatment (P>0.05). After receiving treatment, the gastric atrophy and the intestinal integral scores of the two groups were lower than before (P<0.05). The atrophy and the intestinal integral of the treatment group were lower than those of the control group (P<0.05).The total effective rate of the treatment group was 94.11% and it was better than the control group whose effective rate was 66.05% (P<0.05). Conclusion: Heart-Draining Decoction combined with esomeprazole has a good clinical effect on treating chronic atrophic gastritis and there were no adverse reactions observed, therefore, it is worth a wide clinical application.