To explore the effect of Dan Huang Quyu Capsule and Kangfu Xiaoyan Suppository to the chronic pain of PID and the Partial mechanism. Methods: We chose 120 patients, through random number table, who visited our hospital from April 2012 to March 2014 March for chronic pelvic pain caused by pelvic inflammatory disease as object of the study.They were randomly divided into two groups of 60 cases. The control group was given Kangfu Xiaoyan suppository with bedtime for 2 months by 1 time per day, 1 tablet per time. Observation group, in addition to the treatment that control group recived, taken Dan Huang Quyu capsule oraly by 4 tablets per time, 3 times per day, 10 days as one course and taking for 6 courses.Clinical efficacy were observed andserum tumor necrosis factor (TNF-α) levels, the patients cervical mucus secretory immunoglobulin A (slgA) and TNF-α content were tested. Results: After two months, the two groups of patients with signs and symptoms scores were obtained, and the differences were statistically significant (P<0.05). The observation group decreased more significantly and the difference was statistically significant (P<0.05). After treatment, both groups slAg cervical mucus and TNF-α levels were decreased and the differences were statistically significant (P<0.05). The observation group decreased more significantly wirh differences of statistically significant (P<0.05). Conclusion: Dan Huang Quyu Capsule combining with Kangfu Xiaoyan Suppository could increase content of sIgA and TNF-α in patient cervical mucus is increased, thereby ascending infection defense capabilities. At the same time, it can reduce serum levels of TNF-α so that decrease the immune damage. The therapy could block or inhibit pelvic fibrosisof patients with chronic pelvic inflammatory disease and reduce the symptoms, therefore, it provides target for clinical treatment.