世界中医药

目的：探讨采用丹黄祛瘀胶囊联合康妇消炎栓治疗慢性盆腔炎所致的慢性疼痛的临床疗效观察及相关机制进行探讨。方法：选择本院妇科2012年4月至2014年3月收治的120例盆腔炎所致的慢性盆腔疼痛患者为研究对象，采用随机数字表，随机分为2组，每组60例。对照组予康妇消炎栓睡前肛用，1次/d，1枚/次，连用2月；观察组在对照组基础上加用丹黄祛瘀胶囊治疗，口服4粒/次，3次/d，连服10 d为1个疗程，共服用6个疗程。观察2组的临床疗效，同时观察2组治疗前后血清肿瘤坏死因子(Tumor Necrosis Factor，TNF-α)水平，以及患者宫颈黏液中分泌型免疫球蛋白A(Secretory Immunoglobulin A，sIgA)和TNF-α含量。结果：治疗2个月后，2组患者的症状体征评分均得到下降，差异均具有统计学意义（P<0.05），观察组下降得更明显，差异有统计学意义（P<0.05）；治疗前后，2组血清TNF-α水平均得到下降，差异均具有统计学意义（P<0.05），观察组下降得更明显，差异均具有统计学意义（P<0.05）；治疗前后，2组的宫颈黏液sIAg及TNF-α水平均升高，差异均具有统计学意义（P<0.05），观察组下降得更明显，差异均具有统计学意义（P<0.05）。结论：丹黄祛瘀胶囊联合康妇消炎栓疗法能使慢性盆腔炎患者宫颈黏液中的sIgA、TNF-α的含量升高，从而提高宫颈黏膜对病原微生物反复上行感染的防御能力；同时，其能降低血清中TNF-α水平，从而减轻免疫损伤，阻断或抑制慢性盆腔炎患者盆腔纤维组织增生，进一步减轻盆腔炎患者的症状，为临床提供了治疗靶点。

English Summary:

To explore the effect of Dan Huang Quyu Capsule and Kangfu Xiaoyan Suppository to the chronic pain of PID and the Partial mechanism. Methods: We chose 120 patients, through random number table, who visited our hospital from April 2012 to March 2014 March for chronic pelvic pain caused by pelvic inflammatory disease as object of the study.They were randomly divided into two groups of 60 cases. The control group was given Kangfu Xiaoyan suppository with bedtime for 2 months by 1 time per day, 1 tablet per time. Observation group, in addition to the treatment that control group recived, taken Dan Huang Quyu capsule oraly by 4 tablets per time, 3 times per day, 10 days as one course and taking for 6 courses.Clinical efficacy were observed andserum tumor necrosis factor (TNF-α) levels, the patients cervical mucus secretory immunoglobulin A (slgA) and TNF-α content were tested. Results: After two months, the two groups of patients with signs and symptoms scores were obtained, and the differences were statistically significant (P<0.05). The observation group decreased more significantly and the difference was statistically significant (P<0.05). After treatment, both groups slAg cervical mucus and TNF-α levels were decreased and the differences were statistically significant (P<0.05). The observation group decreased more significantly wirh differences of statistically significant (P<0.05). Conclusion: Dan Huang Quyu Capsule combining with Kangfu Xiaoyan Suppository could increase content of sIgA and TNF-α in patient cervical mucus is increased, thereby ascending infection defense capabilities. At the same time, it can reduce serum levels of TNF-α so that decrease the immune damage. The therapy could block or inhibit pelvic fibrosisof patients with chronic pelvic inflammatory disease and reduce the symptoms, therefore, it provides target for clinical treatment.

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