| 引用本文:杨雪琴，王静.五味消毒饮灌肠治疗慢性盆腔炎的临床疗效观察[J].世界中医药,2015,10(10):. |
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| 五味消毒饮灌肠治疗慢性盆腔炎的临床疗效观察 |
| Clinical Curative Effect Observation on Wuwei Xiaodu Decoction Enema in the Treatment of Chronic Pelvic Inflammation |
| 投稿时间：2015-01-13 |
| DOI：10.3969/j.issn.1673-7202.2015.10.018 |
| 中文关键词: 慢性盆腔炎 五味消毒饮 灌肠 TNF-α |
| English Keywords:Chronic pelvic inflammation Wuwei Xiaodu decoction Enema TNF-alpha |
| 基金项目:2011年四川省卫生厅科研课题立项（编号：110541） |
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| 中文摘要: |
| 目的：观察五味消毒饮灌肠治疗慢性盆腔炎的临床疗效及部分机制。方法：将本院70例慢性盆腔炎随机分为对照组和治疗组，各35例，其中对照组患者口服甲硝唑片及司帕沙星片，连续服用7 d。治疗组在对照组治疗方案基础上加用五味消毒饮灌肠，连续灌肠7 d。比较2组临床疗效、治疗前后简易McGill疼痛评分变化及外周血清TNF-α的浓度变化。结果：1）经过治疗后对照组临床总有效率为80%，治疗组为91.43%,2组比较具有统计学意义（P<0.05）；2）治疗前对照McGill疼痛评分比较差异无统计学意义（P>0.05），治疗7 d后分别与各自治疗前比较，对照组和治疗组P均<0.05，组间比较，2组比较P<0.05治疗组改善较对照组明显。3）2组治疗前TNF-α蛋白表达无明显统计学意义（P>0.05）；治疗7 d后，治疗组的TNF-α蛋白浓度低于对照组；4）McGill疼痛评分与TNF-α存在相关关系（P<0.05）。结论：五味消毒饮灌肠可明显改善慢性盆腔炎的临床症状，其治疗机制可能与下调TNF-α有关。 |
| English Summary: |
| To observe the the clinical curative effect and part of the mechanism of Wuwei Xiaodu decoction enema in the treatment of chronic pelvic inflammation. Methods: A total of 70 cases of patients with chronic pelvic inflammatory diseases in our hospital were randomly divided into the control group and the observation group, with 35 cases in each group. Patients in the control group had oral Metronidazole tablets and Sparfloxacin tablets and took continuously for 7 days.The observation group had Wuwei Xiaodu decoction enema on the basis of the treatment of the control group, continuously for 7 days. To compare the clinical curative effect of the two groups, the changes of simple McGill pain scores before and after the treatment, and TNF-alpha concentration changes in the peripheral blood. Results: 1) After treatment, the clinical total effective rate of the control group was 80%, and the observation group was 91.43%. The comparison between the two groups were of statistically difference(P<0.05); 2) Before therapy against McGill pain score comparison difference has no statistical significance (P>0.05), while after 7 days of treatment, in each group, compared with before each treatment, there were statistical difference(P<0.05). Also, the comparison between two groups shows that there are statistical difference, and the improvement after the treatment in the observation group is more obvious. 3）TNF-alpha protein expression had no obvious differences between the two groups before the treatment (P>0.05), while after 7 days treatment, TNF-alpha protein concentration of the observation group was lower than the control group; 4) The McGill pain scores were correlated with the TNF-alpha (P<0.05). Conclusion: Wuwei Xiaodu decoction enema can obviously relieve the clinical symptoms of chronic pelvic inflammation, and the therapeutic mechanism might be its regulation on TNF-alpha. |
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