Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia, which is featured by proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein). It would cause fracture and bone function failure with a series of clinical symptoms with bad prognosis. The notable Chinese medicine doctor Profosser zhang Jingren has enriched experience and understanding on treating MM, who believes the disease mechanism is due the deficiency of liver-kidney yin, manifested with stasis and phlegm obstruction in channels. The treatment shall pay attention to both supporting right and dispelling evil. Benefiting qi and nourishing yin is applied to treat deficiency syndrome as well as tonifying liver and kidney. To treat excess syndrome, clearing heat and dispelling stasis, cooling blood are applied. This paper explores the TCM cause, mechanism, rules, formula of MM from the clinical experience of professor Zhang Jingren,