To observe the effect of Bushen Lishi Method on gouty arthritis on rat interleukin 17 (IL-17) expression level and to study the mechanism of Bushen Lishi Method in the prevention and treatment of acute gouty arthritis (GA). Methods: A total of 84 Wistar rats were randomly divided into 7 groups: blank group, model group, Chinese medicine control group, western medicine control group and Chinese medicine with low, medium and high dose groups, with 12 rats in each group. Using the model of uric acid sodium combined with potassium oxonate to induce acute gouty arthritis, and then use ELISA method to detect the content of serum IL-17 of rats. Results: Compared with the blank group, the levels of the serum IL-17 of model group rats were significantly increased, and there was a significant difference (P<0.01); compared with the model group, western medicine control group, Chinese medicine control group, Chinese herbal compound in low, high concentration, the level of IL-17 of which were significantly reduced, and there was a significant difference (P<0.01); western medicine control group compared with Chinese herbal compound in middle concentration, the IL-17 content of them had little difference (P>0.01). Conclusion: The prescription of Bushen Lishi Method can reduce the expression of IL-17 in rats with acute gouty arthritis significantly, which has a certain effect on the prevention and treatment of gouty arthritis.