通督调神针刺法对血管性认知障碍患者血清IGF-1表达的影响
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安徽卫生厅中医药科研基金(编号:2012ZJ37);安徽中医药大学青年科研基金(编号:2015qn035);全国名老中医张道宗教授传承工作室建设项目(编号:国中医药人教发[2011]41号);国家中医药管理局“十二五”重点专科脑病科建设项目(编号:国中医药医政发[2012]2号)


Clinical Effect of Dredging Governor Meridian and Regulating Shen Acupuncture Method on the Level of IGF-1 in the Treatment of Vascular Cognition Impairment
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    摘要:

    目的:研究通督调神针刺法治疗血管性认知障碍的临床疗效,并探讨其对IGF-1表达的影响。方法:将72例血管性认知障碍患者随机分为通督调神针刺治疗组(36例)和奥拉西坦对照组(36例),分别于治疗前及治疗35 d后对中医核心症状、MoCA、NPI、MMSE、Hachinski、ADL等量表进行评价,测定治疗前后胰岛素样生长因子-1(IGF-1)水平。结果:通督调神针刺组的中医核心症状量表总有效率明显高于药物对照组,差异具有统计学意义(P<0.05)。治疗组治疗35 d后各量表得分较治疗前改变且明显优于对照组(P<0.05)。治疗后血清IGF-1水平均高于治疗前,但针刺组显著高于药物组,差异具有统计学意义(P<0.05)。结论:通督调神针法能够改善日常生活能力、认知功能及患者伴随的临床症状,提高血管性痴呆患者IGF-1水平,对血管性认知障碍有较好的疗效。

    Abstract:

    To study the clinical efficacy and the effect on the level of insulin-like growth factors-1(IGF-1) of using dredging governer meridian and regulating Shen in the treatment of vascular dementia. Methods: A total of 72 patients with vascular dementia were randomly divided into treatment group(36 patients), which used acupuncture as the therapy, and control group(36 patients), which was given oxiracetam. To evaluate Traditional Chinese Medicine(TCM) core symptoms scales, MoCA scales, NPI scales, MMSE scales, Hachinski scales, ADL scales and measured insulin-like growth factor-1 (IGF-1) levels before treatment and after 35 days of the treatment respectively. Results: The effective rate of TCM core symptoms scales in the acupuncture treatment group was significantly higher than the control group, and the difference was statistically significant (P<0.05). After the 35 days of treatment, the scores of each scale in the treatment group are higher than that of the control group(P<0.05). IGF-1 levels were significantly increased after treatment, and that in the acupuncture group was significantly higher than that of the drug control group, and the difference was statistically significant(P<0.05). Conclusion: Dredging governor meridian and regulating Shen acupuncture method can effectively improve the patients activities of daily living, cognitive function, manifestation, and improve the IGF-1 levels of patients with vascular dementia, which has a good effect on vascular cognitive impairment patients.

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程红亮,胡培佳,张闻东,孙培养,张道宗.通督调神针刺法对血管性认知障碍患者血清IGF-1表达的影响[J].世界中医药,2015,10(10).

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  • 收稿日期:2015-04-03
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  • 在线发布日期: 2015-11-03
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