To explore the clinical characteristic and relevant risk factors of type 2 diabetes with depression.Methods:A total of 636 type 2 diabetes patients from DongFang hospital and five community health service centers,were evaluted Hamilton Depression Rating Scaleand diabetes clinical observation tableat the same time.These patients were divided into the depression group and simple group.Compared various factors associated with disease and physical and chemical indicators.Logistic regression analysis was applied to investigate the risk factors for type 2 diabetes with depression.Results:The 636 diabetes，138(21.7%)were type 2 diabetes with depression.Single facor analysis revealed that the duration of 2 diabetes、the number of complications,exercise、Insulin therapyand glycosylated hemoglobin(HbA1c)existsignificantdifferences between the two groups(P<0.05).Logistic regression analysis shows that the number of complications，exercise,HbA1c were the risk factors of type 2 diabetes with depression patients(P<0.05).Conclusion:Psychological counseling should be taken to the patient with complications，no exercise,and high HbA1c levels.