To observe and analyze the general drugs used in treating psoriasis based on reference reading and the application of Traditional Chinese Medicine Inheritance support software. Methods: Three books recorded the medication of psoriasis are referred to analyze the utilizing frequency of the prescription drugs and association rules among different formulas. Data mining research methods such as Apriori algorithm, based on association rules, complex system entropy cluster and unsupervised hierarchical cluster were used. Results: From the 133 screened prescriptions, the utilizing frequency of the prescription drugs and association rules among different medicines were achieved, and also 20 core drug combinations and 10 new prescriptions were found. Conclusion: This research, which is based on Traditional Chinese Medicine Inheritance support software and data mining method is instructive to clinical treatment of psoriasis and helpful to develop new drugs on psoriasis.