世界中医药

目的：观察芪黄明目胶囊对早期糖尿病视网膜病变的疗效及其对视觉诱发电位P100的影响，以及视觉诱发电位P100的临床意义。方法：随机选取2012年10月至2015年1月，于我院眼科门诊部和住院部就诊的早期DR患者120例，以就诊先后顺序编号，单盲随机数字表法分为观察组和对照组，每组各60例；其中根据第三届全国眼科学术会议制定的DR诊断标准1期患者37例、2期患者41例、3期患者42例。进行视力、眼底荧光素和视觉诱发电位等眼科检查。结果：1）治疗前观察组和对照组组视力比较差异均无统计学意义（P>0.05），治疗后观察组视力优于对照组（P<0.05），2组治疗后视力均优于治疗前（P<0.05）。2）观察组总有效率为86.67%，对照组总有效率为75.00%。经χ2检验，观察组优于对照组（P<0.05）。3）治疗前观察组和对照组组视觉诱发电位P100的潜时、幅值比较差异均无统计学意义（P>0.05），治疗后观察组视觉诱发电位P100潜时短于对照组（P<0.05），视觉诱发电位P100幅值高于对照组（P<0.05），2组治疗后视觉诱发电位P100潜时和幅值均与治疗前差异有统计学意义（P<0.05）。4）治疗后早期DR各期均与P100潜时和幅值有明显的相关性，早期DR患者随着病情由1-3期的进展，视觉诱发电位P100潜时明显延长（P<0.05），幅值明显下降（P<0.05）。结论：芪黄明目胶囊在治疗早期DR疗效显著，有助于提高早期DR患者视力，缩短视觉诱发电位P100的潜时和提高P100的幅值。视觉诱发电位P100不仅具有早期诊断价值，还可以预测早期DR的病情进展。

English Summary:

To observe the curative effect of Qihuang Mingmu capsule on treating early diabetic retinopathy (DR) and its influence on visual evoked potentials P100. Methods: To select randomly from 120 early DR patients who either treated in ophthalmology outpatient department or inpatient department in our hospital from October 2012 January 2015. After numbered them according to their enrollment time, these patients were divided into control group and observation group with a random number tale, 60 cases in each. With the reference to the diagnostic criteria issued by the 3rd Congress of Ophthalmology, it was found that among these patients, there were 37 cases in stage 1, 41 cases in stage 2 and 42 cases in stage 3. The ophthalmic examinations such as visual acuity, fundus fluorescein and visual evoked potential(VEP) were conducted. Results: 1.Before treatment, visual acuity of the observation group and the control group showed no significant difference (P>0.05). After treatment, the observation group vision acuity performed better than the control group (P<0.05), and both groups performed better than before the treatment (P<0.05). 2.The total effective rate of the observation group was 86.67% and control group was 75%. The observation group was better than the control group (P<0.05) by X2 test. 3. Before treatment, the two groups showed no significant difference (P>0.05) in the aspects of VEP P100 latency and amplitude. After treatment, latent time of VEP P100 in the treatment group was shorter than the control group(P<0.05) and its amplitude was higher that that of the control group(P<0.05). 4. After treatment, there are correlations between early DR stages and P100 latency and amplitude. Along with the disease development from stage1 to 3, VEP P100 latency was significantly prolonged (P<0.05) and amplitude decreased obviously (P<0.05). Conclusion: Qihuang Mingmu capsule is effective to treat early DR and can improve vision acuity, also to shorten the latent VEP P100 and improve the P100 amplitude. The VEP P100 can both help to early diagnose DR and to predict its early development.

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