世界中医药

目的：探讨穴位埋线对单纯性肥胖的作用机理。方法：采用高脂饮食喂养建立肥胖模型大鼠，将造模成功大鼠进行埋线治疗干预后，观察大鼠体重、体长、Lee’s指数的变化及检测血清脂联素及其受体的含量。结果：经治疗后，埋线组大鼠的体重、Lee’s指数均明显低于对照组而高于正常组(P<0.01，P<0.05)。雌雄埋线组大鼠治疗前后体重差值的比较，其结果显示雄性大鼠减肥疗效优于雌性(P<0.01)。对照组、埋线组大鼠血清ADP、AdipoR1的含量均明显低于正常组(P<0.01)，而AdipoR2的含量高于正常组(P<0.01)；经埋线治疗后，肥胖大鼠血清ADP、AdipoR1的含量升高(P<0.01，P<0.05),而AdipoR2的含量降低(P<0.01)。结论：穴位埋线对肥胖机体脂联素及其受体水平的良性调节作用可能是埋线疗法减肥的作用机制之一。

English Summary:

To investigate the mechanism of catgut implantation at acupoint on simple obesity. Methods:To establish the model of obesity rats by providing high lipid diet. To observe the change of rats’ body weight, body length, Lee ’s index and test the content of serum adiponectin and its receptors after its intervention of catgut embedding therapy. Results: after treatment, the rats of catgut embedding group’s body weight, Lee ’s index were all markedly lower than the control group but still higher than the normal group(P<0.01, P<0.05). Comparison between the weight of male and female catgut embedding group rats before and after treatment shows that male rats weight loss efficacy is superior to female(P<0.01). The levels of serum ADP and AdipoR1 in the control and catgut embedding groups were all markedly lower than that in the normal group(P<0.01), but the level of serum AdipoR2 was higher than normal(P<0.01). After treatment of catgut embedding, the levels of obese rats’ serum ADP and AdipoR1 were rised(P<0.01, P<0.05), while it saw a decrease of AdipoR2(P<0.01). Conclusion: Catgut implantation at acupoint can have benign effect on adiponectin and its receptor levels of obese bodies, and this may be one of the mechanism of catgut embedding therapy of losing weight.

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