| 引用本文:姚东，胡北，高军，郭晓欢，马宏达，安晔.心脑脉舒口服液质量控制与降血脂作用相关研究[J].世界中医药,2015,10(11):. |
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| 心脑脉舒口服液质量控制与降血脂作用相关研究 |
| Research on the Correlation between the Quality of Xinnao Maishu Oral Solution and its Hypolipidemic Effect |
| 投稿时间：2015-03-19 |
| DOI：10.3969/j.issn.1673-7202.2015.11.037 |
| 中文关键词: 心脑脉舒口服液 羟基红花黄色素A 高效液相色谱法 降血脂 |
| English Keywords:Xinnao Maishu oral solution Hydroxysafflor A HPLC Hypolipidemic |
| 基金项目:军队医疗机构制剂标准提高科研专项课题面上项目（编号：13ZJZ01-3）；辽宁省自然科学基金项目(编号：2013020182) |
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| 中文摘要: |
| 目的：探索心脑脉舒口服液中羟基红花黄色素A含量与高脂血症大鼠降血脂作用的相关性。方法:采用高效液相色谱法建立羟基红花黄色素A含量测定方法，测定高脂血症大鼠血清三酰甘油（Triglyceride，TG）、胆固醇(Cholesterol，TC)、高密度脂蛋白(Highdensitylipoprotein，HDL-C)、低密度脂蛋白(Low Densith Lipoprotein，LDL-C)的含量。结果：羟基红花黄色素A含量测定方法准确性、重复性良好，羟基红花黄色素A的含量与高脂血症大鼠降血脂作用存在一定相关性。结论：羟基红花黄色素A可作为心脑脉舒口服液质量控制指标。 |
| English Summary: |
| To explore the correlation between the content of hydroxysafflor A in Xinnao Maishu oral solution and hypolipidemic effect in hyperlipidemia rats. Methods: The content of hydroxysafflor A in Xinnao Maishu oral solution was determined by High Performance Liquid Chromatography(HPLC), and the content of serum cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) in hyperlipidemic rats were determined. Results: The method of hydroxysafflor A content determination is accurate and reproducible. The results showed that there was a certain correlation between the content of hydroxysafflor A and hypolipidemic effect. Conclusion: The content of hydroxysafflor A can be used as the quality control index of Xinnao Maishu oral solution. |
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