| 引用本文:赵森1，慕杨娜2，姜黎1，邹明1.单因素法优化两面针提取工艺[J].世界中医药,2015,10(11):. |
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| 单因素法优化两面针提取工艺 |
| Single-factor Optimization for Extraction Process of Radix Zanthoxyli |
| 投稿时间：2014-08-19 |
| DOI：10.3969/j.issn.1673-7202.2015.11.038 |
| 中文关键词: 两面针 总生物碱 单因素法 高效液相色谱 |
| English Keywords:Radix Zanthoxyli Total alkaloid Single factor optimization method HPLC |
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| 中文摘要: |
| 目的：优化两面针药材的提取工艺。方法：采用单因素考察方法，以提取时间，提取次数，提取溶剂、用量、浓度及PH值作为优选因素，以两面针中的氯化两面针碱提取量和出膏率作为定量指标，优化提取工艺。结果：最佳的提取工艺条件是：乙醇浓度80%，加醇量为8倍，提取2次，每次提取2 h，加入0.1 mol/L盐酸调乙醇pH至5，出膏率和有效成分提取率比较高，重现性好。结论：优化的提取工艺稳定可行，适合工业大生产要求。 |
| English Summary: |
| To optimize extraction process of Radix zanthoxyli. Methods:By using a single factor optimization method, we selected a reasonable extraction process via ethyl alcohol. Optimizing factors are extraction time, number of extractions, extraction solvent, dosage, concentration, PH value; using yield rate and Nitidine Chloride extracted weight as parameters. Results:The optimum extraction process is 80% concentration of ethyl alcohol, extract 2 h each time, extract twice, controlling pH=5 using 0.1 mL/L HCL. Conclusion:The optimized extraction process is suitable for industrial production. |
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